Gastroenterology. 2016 Apr
Defective Intestinal Mucin-type O-glycosylation Causes Spontaneous Colitis-associated Cancer in Mice.

Cell Stem Cell. 2016 Apr
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.

Oncotarget. 2016 Feb
Serum CA125 is a novel predictive marker for pancreatic cancer metastasis and correlates with the metastasis-associated burden.

Oncotarget. 2015 Nov
Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism.

Curr Pharmacol Rep. 2015 Aug
Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.

Oncotarget. 2015 Oct
Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal.

Altern Ther Health Med. 2015
An Ethanol Extract of Hawaiian Turmeric: Extensive In Vitro Anticancer Activity Against Human Colon Cancer Cells.

Oncotarget. 2015 Sep
ZIP4 silencing improves bone loss in pancreatic cancer.

PLoS One. 2015 Aug
Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis.

Lab Invest. 2015 Nov
Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.

PLoS One. 2015 Aug
Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury.

Oncotarget. 2015 Aug
Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases.

Oncotarget. 2015 Jun
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.

PLoS One. 2015 Feb
Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells.

Oncotarget. 2015 Feb
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma.


Digestive Diseases and Sciences
DCLK1 is detectable in plasma of patients with Barrett’s esophagus and esophageal adenocarcinoma.

Oncotarget Oct 2014
DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition.

New York Academy of Sciences Sep 2014
Translational research on Barrett’s esophagus.

The World Journal of Gastrointestinal Oncology 2014 Jul
Patient prompting of their physician resulted in increased colon cancer screening referrals.

Molecular Cancer 2014 May
Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1.

Cancer Letters 2014 Aug
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.

The World Journal of Gastroenterology 2014 Feb
Intestinal stem cells and the colorectal cancer microenvironment.

Journal of Clinical Investigation 2014 Mar
Long-lived intestinal tuft cells serve as colon cancer-initiating cells.

The American Journal of Physiology 2014 Mar
Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury.


PLoS One. 2013 Nov
Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism.

Molecular Carcinogenesis 2013 Oct
Reg4-induced mitogenesis involves Akt-GSK3β-β-Catenin-TCF-4 signaling in human colorectal cancer.

Stem Cells. 2013 Oct
Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury.

PLoS One. 2013 Sep
DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug
A multi-center study to standardize reporting and analyses of fluorescence-activated cell sorted murine intestinal epithelial cells.


Methods Mol Biol. 2012
Preparation of siRNA-encapsulated PLGA nanoparticles for sustained release of siRNA and evaluation of encapsulation efficiency.

Am J Pathol. 2012 Jun
Epigenetic variants and biomarkers for colon cancer.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun
A nomenclature for intestinal in vitro cultures.

Inflamm Bowel Dis. 2012 May
Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis.

J Gastroenterol Hepatol. 2012 Apr
Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett’s esophagus and esophageal adenocarcinoma.


PLoS One. 2011 Feb 11
RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.

Cancer Res. 2011 Mar
DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.


In Vivo. 2010 Nov-Dec
Urine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assay.

J Nanobiotechnology. 2010 Jul
Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP.

Am J Physiol Gastrointest Liver Physiol. 2010 Aug
Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas.

Curr Colorectal Cancer Rep. 2010 Mar
Role of RNA-Binding Proteins in Colorectal Carcinogenesis.

Mini Rev Med Chem. 2010 May
Cancer stem cells: a novel paradigm for cancer prevention and treatment.

Altern Ther Health Med. 2010
Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo.

Gastroenterology. 2010 Feb
Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis.


Stem Cells. 2009 Oct
Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively.

Anticancer Res. 2009 Jun
14-3-3sigma-dependent resistance to cisplatin.

Gastroenterology. 2009 Aug
Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism.

Gastroenterology. 2009 May
HuR and TTP: two RNA binding proteins that deliver message from the 3′ end.

Am J Physiol Gastrointest Liver Physiol. 2009 Feb
Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury.


Cancer Res. 2008 Dec
Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect.

Cancer Res. 2008 Oct
Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos.

J Med Microbiol. 2008 Oct
Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression.

Gastroenterology. 2008 May
Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.

Gastroenterology. 2008 Apr
Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms.

Cancer Res. 2008 Mar
Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity.

Am J Physiol Gastrointest Liver Physiol. 2008 May
CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe.

Am J Physiol Gastrointest Liver Physiol. 2008 Apr
Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2.

Am J Physiol Gastrointest Liver Physiol. 2008 Apr
Novel intestinal splice variants of RNA-binding protein CUGBP2: isoform-specific effects on mitotic catastrophe.

Stem Cells. 2008 Mar
Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice.

Inflamm Bowel Dis. 2008 Jan
Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis.


Gastroenterology. 2007 Mar
Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation.

Prostaglandins Other Lipid Mediat. 2007 Feb
EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway.


Cancer Biol Ther. 2006 Dec
Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes.

Am J Physiol Gastrointest Liver Physiol. 2006 Dec
Azoxymethane protects intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism.

Gastroenterology. 2006 Jan
Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas.

Prior to 2006

Protein Expr Purif. 2005 Dec
PEGylated murine Granulocyte-macrophage colony-stimulating factor: production, purification, and characterization.

Gastroenterology. 2004 Oct
Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression.

Proc Natl Acad Sci U S A. 2004 Sep
Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage.

Ann N Y Acad Sci. 2003 Dec
CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury.

Inflamm Bowel Dis. 2003 Mar
FGF-20: FGFs–they keep growing and growing and growing!

Mol Cell. 2003 Jan
Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.

Am J Physiol Gastrointest Liver Physiol. 2003 Mar
Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine.

J Investig Med. 2002 Nov
Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity.